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August 25, 2025Open Access

Resolving plasmid-encoded carbapenem resistance dynamics and reservoirs in a hospital setting through nanopore sequencing

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Authors

ESEla SauerbornRWRhys T. WhiteAKAnna-Lena Kalteis

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Overview

This analysis reveals carbapenem resistance mechanisms in Enterobacterales, implying risks associated with hospital drains.

Key Points

  • Carbapenem resistance dynamics were assessed, revealing ongoing spread and persistence in hospital settings.
  • Long-read nanopore sequencing identified plasmid-mediated resistance, providing insights into infection control methods.
  • Routine clinical methods were insufficient, whereas sequencing enabled detailed genetic profiling and strain tracking.
  • Findings underscore the significance of environmental reservoirs, especially drains, in the transmission of resistance genes.

Cite This Study

Sauerborn et al. (2025) studied this question.

synapsesocial.com/papers/68af7b187567bf4f94ff293fhttps://doi.org/10.1101/2025.08.20.671332
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