Molecular and Clinicopathological Profiling of Clear Cell Renal Cell Carcinoma with Rhabdoid Features: An Integrative Pathway-Based Stratification Approach
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Key Points
Tumors exhibited distinct histological features, including prominent nucleoli and specific growth patterns, emphasizing aggressive behavior.
Pathway-specific analysis revealed four molecular subgroups based on key alterations in genes related to DNA damage repair and chromatin remodeling.
Assessment involved comprehensive methods including immunohistochemistry and next-generation sequencing to depict the tumor landscape.
Findings support the development of precision oncology strategies based on identified molecular heterogeneity, aiding clinical trial design.
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