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August 25, 2025Journal of Clinical MicrobiologyOpen Access

Paradoxical carbapenemase activity detected by modified carbapenemase inactivation (mCIM) method in Citrobacter sedlakii

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Authors

DBD. Garrett BrownMSMichael G. SuretteSRSreejana Ray

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Overview

Case study reveals mCIM may inaccurately suggest carbapenemase production in Citrobacter sedlakii, highlighting testing limitations.

Key Points

  • False-positive results for carbapenemase production were observed, prompting need for accurate testing methods.
  • The modified carbapenemase inactivation method indicated carbapenemase activity despite non-resistance to carbapenems.
  • Whole-genome sequencing confirmed only the presence of a class A β-lactamase, with no carbapenemase detected.
  • Utilization of large inoculums in testing may contribute to erroneous detection of carbapenemase production.

Cite This Study

Brown et al. (2025) studied this question.

synapsesocial.com/papers/68af79b67567bf4f94ff2152https://doi.org/10.1128/jcm.00589-25
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