Reliability and Validity of Health-Related Quality of Life Instruments for Breast Cancer Patients in Asia: A Systematic Review and Meta-Analysis

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EORTC QLQ-C30 and QLQ-BR23 demonstrated strong reliability with pooled Cronbach's alpha values of 0.881 and 0.860, respectively.
Five studies involving 818 patients provided evidence of reliability, although validity data was inconsistently reported.
Meta-analysis showed high heterogeneity in results, mainly due to variations in patient populations and research designs.
Significant cultural diversity in Asia indicates a need for standardized methodologies to enhance the tools' applicability.

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Systematic review and meta-analysis reveals reliability of HRQoL tools for breast cancer, suggesting improvements needed for validity.

Weny et al. (2025) studied this question.

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