Integrative bioinformatics and drug repurposing for metastatic prostate cancer: identifying novel therapeutic targets by transcriptional profiling and molecular Modeling

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Discussion

Analysis identifies therapeutic targets and compounds for prostate cancer metastasis, suggesting new treatment avenues.

Identified three compounds—Prunetin, Ofloxacin, and ALW-II-49-7—that may improve survival in metastatic prostate cancer, enhancing treatment efficacy.
Differential genes were identified from four GEO datasets, with further analysis using network tools revealing potential hub genes.
Integrative approach included molecular docking and dynamics simulations to evaluate drug binding efficiency for newly identified targets.
Findings indicate novel therapeutic targets, warranting further validation through in vitro and in vivo studies to ensure efficacy.

Nisar et al. (2025) studied this question.

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