August 1, 2025eJHaemOpen Access

Hemoglobin and High‐Density Lipoprotein as Biomarker of Left Atrial Dilatation in Sickle Cell Disease

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Left atrial dilatation occurred in 61% of subjects, alongside significant biomarkers associated with SCD.
Key findings included hemoglobin ≤ 9.7 g/dL and HDL-C ≤ 50 mg/dL as indicators for cardiac risk.
Evaluation used echocardiography on 59 adult sickle cell disease patients to explore cardiac abnormalities.
Biomarker-based screening for cardiac complications may improve early detection in resource-limited settings.

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Echocardiography shows left atrial dilatation in 61% of SCD patients, indicating hemoglobin and HDL may predict cardiac issues.

Feugray et al. (2025) studied this question.

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