August 23, 2025JDDG Journal der Deutschen Dermatologischen GesellschaftOpen Access

Low‐dose total skin electron beam therapy in erythrodermic mycosis fungoides and Sézary syndrome: Results From the Prospective S‐MISR Study

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Treatment achieved an overall response rate of 89% at 3 months post-therapy, implying its effectiveness for erythrodermic mycosis fungoides and Sézary syndrome.
Patients reported significant reductions in pruritus and improvements in health-related quality of life scores, highlighting treatment benefits beyond skin symptoms.
The median time to next treatment was 20 months, and progression-free survival averaged 14 months, reflecting long-term disease management.
Only 6% of patients experienced grade ≥3 radiation-related toxicity, suggesting a favorable safety profile for total skin electron beam therapy.

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Implication

Prospective analysis shows 89% response rate with total skin electron beam therapy in 35 patients, indicating long-term disease control and quality of life improvements.

Cite This Study

Elsayad et al. (2025) studied this question.

synapsesocial.com/papers/68af76b97567bf4f94fefa16 https://doi.org/10.1111/ddg.15851

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Implication

Prospective analysis shows 89% response rate with total skin electron beam therapy in 35 patients, indicating long-term disease control and quality of life improvements.

Low‐dose total skin electron beam therapy in erythrodermic mycosis fungoides and Sézary syndrome: Results From the Prospective S‐MISR Study

Key Points

Discussion

Implication

Cite This Study

Low‐dose total skin electron beam therapy in erythrodermic mycosis fungoides and Sézary syndrome: Results From the Prospective S‐MISR Study

Key Points

Discussion

Implication

Cite This Study