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August 22, 2025Journal of the American Heart AssociationOpen Access

Coronary Chronic Total Occlusions Affect Long‐Term Prognosis in Heart Failure With Mildly Reduced Ejection Fraction

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Authors

MBMichael BehnesMSMoritz SchmidbergerKMKambis Mashayekhi

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Overview

Analysis correlates coronary chronic total occlusions with worse outcomes in heart failure patients, suggesting new intervention strategies.

Key Points

  • Patients with coronary chronic total occlusions experienced a higher long-term all-cause mortality rate at 33% compared to 19% in non-CTO patients.
  • Invasive coronary angiography revealed that 17% of heart failure with mildly reduced ejection fraction patients had at least one chronic total occlusion.
  • This observational analysis focused on 1545 patients with heart failure, highlighting the association of coronary occlusions with adverse outcomes.
  • Successful treatment of CTO by percutaneous coronary intervention significantly improved long-term survival, suggesting critical therapeutic implications.

Cite This Study

Behnes et al. (2025) studied this question.

synapsesocial.com/papers/68af76b27567bf4f94fef5cdhttps://doi.org/10.1161/jaha.125.042368
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1European Society of Cardiology Heart Failure Long-Term Registry (ESC-HF-LT): 1-Year Follow-Up Outcomes and Differences Across Regions2016 · 797 citations
  2. 2Classification of the cardiomyopathies: a position statement from the european society of cardiology working group on myocardial and pericardial diseases2007 · 3,029 citations
  3. 3Current Perspectives on Coronary Chronic Total Occlusions2012 · 809 citations