Prospective cohort study assesses relationship between platelet indices and disease severity in children with SCA, indicating no significant correlation.
Key Points
Platelet indices are higher during vaso-occlusive crises compared to steady state, but the difference is not clinically significant.
Key findings show that platelet count and plateletcrit are elevated during crises, while platelet distribution width decreases.
The prospective cohort involved sixty children with SCA, and multiple platelet indices were measured to assess disease severity.
Results suggest that platelet-modifying treatments may not be necessary for managing disease severity in children with SCA.