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August 22, 2025Open Access

The genetic architecture of the human bZIP family

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Authors

ABAlexandra M. BendelBEBastian EichenbergersGKGeorg Kempf

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Overview

Quantitative deep mutational scanning reveals context dependency in protein interactions, indicating complex genetic architecture.

Key Points

  • Mutation effects on bZIP interactions display strong context dependency, complicating predictive modeling.
  • Around 2 million interaction measurements were collected, revealing the complexity of protein function.
  • Analysis utilized deep mutational scanning, which provides insights into protein-protein interaction dynamics.
  • Convolutional neural network modeling could accurately predict binding scores from sequence alone, facilitating bioengineering.

Cite This Study

Bendel et al. (2025) studied this question.

synapsesocial.com/papers/68af76ad7567bf4f94fef3cfhttps://doi.org/10.1101/2025.08.21.671354
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