August 22, 2025Open Access

Decreased social, drug, and food reward sensitivity in adolescent mice

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Discussion

Investigation reveals decreased reward sensitivity in adolescent mice, highlighting developmental effects on social and food rewards.

Adolescent mice show significantly reduced conditioned place preference compared to adults, indicating lower reward sensitivity.
Compared to adult mice, those in mid-adolescence exhibited lesser preference for social and palatable food rewards.
Conditioned place preference tasks highlight age as the primary factor affecting reward sensitivity, with minimal effects from sex.
Findings suggest that decreased reward sensitivity in adolescents stems from developmental changes rather than learning deficits.

Misiołek et al. (2025) studied this question.

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