August 22, 2025Science AdvancesOpen Access

Size-dependent temporal decoupling of morphogenesis and transcriptional programs in pseudoembryos

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Larger gastruloids exhibit delayed symmetry breaking and prolonged axial elongation, affecting morphogenetic outcomes.
Morphogenetic timing varies with system size, yet transcriptional programs remain stable across different sizes.
Analysis utilized quantitative live imaging and transcriptomic profiling across various gastruloid sizes.
Findings highlight gastruloids' adaptability in development, revealing physical constraints that decouple morphogenesis from gene expression.

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Quantitative analysis reveals size affects morphogenesis in gastruloids, indicating gene expression stability despite size variations.

Bennabi et al. (2025) studied this question.

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