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August 22, 2025Journal of Personalized MedicineOpen Access

Polygenic Risk Score Associated with Gestational Diabetes Mellitus in an AmericanIndian Population

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Authors

KPKathryn A. PetersonCPCamille E. PoweQSQuan Sun

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Overview

Case-control analysis reveals associations between polygenic risk score and gestational diabetes, highlighting genetic factors.

Key Points

  • Gestational diabetes mellitus is positively associated with body mass index and age, suggesting lifestyle factors influence risk.
  • The polygenic risk score comprising seven variants indicated a trend towards increased risk with an odds ratio (OR) of 1.56.
  • Multivariate logistic regression methods were used to analyze genetic variants associated with gestational diabetes among women.
  • Findings emphasize the need for studying genetic background in relation to polygenic risk scores for diabetes.

Cite This Study

Peterson et al. (2025) studied this question.

synapsesocial.com/papers/68af75277567bf4f94feece1https://doi.org/10.3390/jpm15090395
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