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August 21, 2025MicroorganismsOpen Access

BCL-2 Multi-Strain Probiotics for Immunomodulation In Vitro and In Vivo Alleviation of Atopic Dermatitis

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Authors

MSMoon‐Hee SungKookmin UniversitySSSeongrok SimALAhyoung LimLondon School of Hygiene & Tropical Medicine

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Implication

In vivo findings show BCL-2 probiotics reduce inflammation and improve skin barrier in atopic dermatitis, indicating a robust immunomodulatory effect.

Key Points

  • BCL-2 probiotics significantly improved clinical signs of atopic dermatitis in mice, enhancing skin health throughout the study.
  • IL-4 secretion decreased notably with BCL-2 treatment, showing superior results compared to single-strain probiotics.
  • Oral administration of BCL-2 probiotics for 28 days altered immune responses, decreasing inflammation-related cytokines and chemokines.
  • These findings suggest BCL-2 probiotics could serve as a safer alternative for managing atopic dermatitis effectively.

Cite This Study

Sung et al. (2025) studied this question.

synapsesocial.com/papers/68af75277567bf4f94feeb7fhttps://doi.org/10.3390/microorganisms13081950
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