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August 21, 2025Journal of sickle cell disease.

Clinical phenotype of high-impact chronic pain in sickle cell disease at consultation for hematopoietic cell transplant

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Authors

SHSerena HuangEmory UniversitySGScott GillespieEmory UniversityECEric ChouEmory University

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Implication

Retrospective study identifies chronic pain patterns in 46 children with sickle cell disease, suggesting screening for high-impact chronic pain may reduce morbidity.

Key Points

  • High-impact chronic pain significantly affects morbidity in children with sickle cell disease, indicating a need for improved assessment.
  • Among 46 children, 84.8% had HbSS genotype, 30.4% experienced avascular necrosis, and 41.3% were prescribed adjuvant analgesics.
  • Healthcare utilization for pain increased annually by 15%, with some patients exhibiting low-frequency pain episodes despite chronic pain.
  • Screening for high-impact chronic pain may be crucial to identify those at risk of poor health outcomes during hematopoietic cell transplant.

Cite This Study

Huang et al. (2025) studied this question.

synapsesocial.com/papers/68af75277567bf4f94feea6bhttps://doi.org/10.1093/jscdis/yoaf028
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Also Consider

Synapse has enriched one closely related paper. Consider it for comparative context:

  1. 1Prevalence of chronic pain in the UK: a systematic review and meta-analysis of population studies2016 · 1,393 citations