Histopathological insights into dysgenetic gonads: A comprehensive case series analysis

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Retrospective analysis reveals 10 cases of sertoli cell syndrome in phenotypic females, suggesting the need for multidisciplinary approaches.

A total of 10 patients diagnosed with sertoli cell syndrome were identified, highlighting the prevalence of this condition in phenotypic females.
Patients had a mean age of 21 years, with case ages ranging from 15 to 29 years, illustrating the diversity in presentation of the syndrome.
Histopathological analysis revealed hypospermatogonia and predominant sertoli cells, indicating abnormal testicular tissue structure.
Comprehensive evaluation and genetic techniques such as chromosomal karyotyping can enhance diagnosis and inform treatment strategies.

Mishra et al. (2025) studied this question.

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Retrospective analysis reveals 10 cases of sertoli cell syndrome in phenotypic females, suggesting the need for multidisciplinary approaches.