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August 22, 2025Frontiers in HematologyOpen Access

Case report: A case of intravascular large B-cell lymphoma and related literature review

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Authors

WZWen ZhouAcademy of Medical SciencesXGXiaojia GuoAcademy of Military Medical SciencesYLYang LiuGuiyang College of Traditional Chinese Medicine

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Implication

Case Report highlights diagnosis of intravascular large B-cell lymphoma in a patient with secondary hemophagocytic syndrome, implying diagnostic challenges.

Key Points

  • Patient diagnosed with intravascular large B-cell lymphoma after developing symptoms including chest tightness and dyspnea, posing significant diagnostic challenges.
  • Laboratory tests revealed persistent hypoalbuminemia and elevated lactate dehydrogenase, indicating serious underlying pathology linked to lymphoma and hemophagocytic syndrome.
  • Treatment involved four cycles of zanubrutinib with R-CHOP, leading to resolution of symptoms and normalization of laboratory parameters, highlighting effective therapy.
  • Patient showed suboptimal adherence to treatment plan, emphasizing the importance of compliance; disease status unknown at follow-up after two years.

Cite This Study

Zhou et al. (2025) studied this question.

synapsesocial.com/papers/68af736e7567bf4f94fedbcfhttps://doi.org/10.3389/frhem.2025.1639726
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