Analysis of the clinical diagnostic efficacy of the novel serum markers lipase F, gastrokine 2 and the collagen X-type α1 chain in gastric cancer

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Analysis reveals serum markers COL10A1, GKN2, and LIPF improve diagnostics for gastric cancer, suggesting clinical utility.

Detecting three serum markers significantly improves gastric cancer diagnosis accuracy and aids early detection.
ROC curve analysis showed an AUC of 0.877 for early gastric cancer detection with new markers compared to 0.843 for conventional markers.
A total of 108 subjects were analyzed, with 60 being gastric cancer patients, enhancing the study's clinical relevance.
Combining new markers with traditional markers shows AUC values of 0.963, supporting the value of these diagnostics.

Wang et al. (2025) studied this question.

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