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August 22, 2025Frontiers in MicrobiologyOpen Access

Antifungal activity of cinnamaldehyde against Aspergillus fumigatus involves disruption of the TCA cycle and protein metabolism

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Authors

FLFang LiXCXi ChengLLLing Li

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Overview

Analysis reveals cinnamaldehyde's antifungal activity disrupts metabolic pathways in Aspergillus fumigatus, suggesting new treatment options.

Key Points

  • Cinnamaldehyde shows potent antifungal activity against A. fumigatus, reducing growth at 40–80 µg/mL concentrations.
  • In proteomic and metabolomic analyses, 167 proteins and 350 metabolites were significantly altered after treatment with cinnamaldehyde.
  • The study employed susceptibility tests and quantitative spore viability assays to determine antifungal efficacy against resistant strains.
  • Cinnamaldehyde may provide a valuable alternative to traditional antifungal agents, particularly against resistant A. fumigatus strains.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68af736e7567bf4f94fedb6chttps://doi.org/10.3389/fmicb.2025.1613987
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