August 22, 2025Frontiers in MedicineOpen Access

Circulating microRNAs as biomarkers for ischemic heart disease: a systematic review and gene set enrichment analysis

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A panel of recurrently dysregulated microRNAs may enhance diagnostic value for ischemic heart disease, implicating multiple biological processes.
The systematic review included 38 studies that revealed consistent dysregulation of microRNAs like miR-126 and miR-21 in various ischemic heart disease subtypes.
Gene set enrichment analysis showed that the identified microRNAs are involved in critical pathways such as angiogenesis and apoptosis.
These findings highlight the potential of microRNAs as non-invasive diagnostic tools for ischemic heart disease, though further validation is needed.

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Systematic review evaluates microRNAs as biomarkers for ischemic heart disease, suggesting diagnostic potential in various pathways.

Alcibahy et al. (2025) studied this question.

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