August 22, 2025VirusesOpen Access

A Pan-H5N1 Multiepitope DNA Vaccine Construct Targeting Some Key Proteins of the Clade 2.3.4.4b Using AI-Assisted Epitope Mapping and Molecular Docking

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Analysis reveals a promising multiepitope DNA vaccine for H5N1 in chickens, suggesting enhanced immune response mechanisms.

The designed vaccine may stimulate a strong immune response in birds, particularly chickens and other species.
Results indicate successful binding of predicted epitopes to MHC molecules, suggesting effective immune activation.
This research utilizes AI-assisted epitope mapping and molecular docking to improve vaccine design for H5N1.
Potentially offers a broad protection solution against HPAI-H5N1 clade 2.3.4.4b; further validation in chickens needed.

Duraisamy et al. (2025) studied this question.

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