This research demonstrates that ethanolic extract of Tabernaemontana catharinensis reduces cell viability in MCF-7 and MDA-MB-231 lines, indicating strong therapeutic potential.
Key Points
Ethanolic extract significantly reduced cell viability in MCF-7 and MDA-MB-231, indicating effectiveness against breast cancer.
IC50 values were notably lower in MDA-MB-231 at 8.3 µg/mL compared to 83.06 µg/mL for MCF-7 cells, suggesting stronger potency.
Treatment with EET caused G1 phase cell cycle arrest and significantly reduced CDK4 activity by 58%, highlighting its mechanism of action.
EET also induced apoptosis through caspase activation, coupled with mitochondrial dysfunction, supporting its role as an antitumor agent.
Cite This Study
Martínez-Méndez et al. (2025) studied this question.