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August 22, 2025Acta PhysiologicaOpen Access

NMDA‐Type Glutamate Receptor Activation Promotes Ischemic Arrhythmias by Targeting the AKT1–TBX3–Nav1.5 Axis

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Authors

YHYuxian HeHZHan ZhangQZQinggang Zhang

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Overview

Assessment reveals NMDAR influences ventricular arrhythmias in ischemic heart disease, suggesting therapeutic targets via the AKT1–TBX3–Nav1.5 axis.

Key Points

  • NMDAR activation contributes to ventricular arrhythmias in myocardial infarction, suggesting novel therapeutic avenues.
  • Inhibition of NMDAR significantly reduces the occurrence of ventricular arrhythmias in preclinical models.
  • Analysis of heart tissue showed distinct electrophysiological remodeling following NMDAR activation, impacting crucial ion channels.
  • The regulation of the AKT1–TBX3–Nav1.5 axis emerges as a pivotal mechanism in the pathogenesis of arrhythmias post-MI.

Cite This Study

He et al. (2025) studied this question.

synapsesocial.com/papers/68af73637567bf4f94fed0a2https://doi.org/10.1111/apha.70085
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  5. 5Mitochondrial dysfunction as a central hub linking Na+/Ca2+ homeostasis and inflammation in ischemic arrhythmias: therapeutic implications2025