January 1, 2025Open MedicineOpen Access

Assessment of SOX2 performance as a marker for circulating cancer stem-like cells (CCSCs) identification in advanced breast cancer patients using CytoTrack system

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Image-based analysis identified CCSCs in CTC clusters of advanced breast cancer patients, suggesting SOX2 may play a role in therapy resistance.

CCSCs were identified in only 2 out of 60 advanced breast cancer patients, indicating their rarity.
The method achieved a recovery ratio of approximately 60% for CCSCs identification from patient samples.
Participants' samples revealed that SOX2 expression was present in primary tumor tissue, suggesting potential relevance.
Findings highlight the possibility of stem-like reprogramming occurring early in primary tumors, potentially impacting therapy outcomes.

Szostakowska-Rodzoś et al. (2025) studied this question.

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Image-based analysis identified CCSCs in CTC clusters of advanced breast cancer patients, suggesting SOX2 may play a role in therapy resistance.