August 22, 2025Open Access

Spatial and Single-Cell Dissection of Fibroblast Subpopulation Reprogramming Driving Stromal Collapse in Breast Cancer Lymph Node Metastasis

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Fibroblast subpopulations play a central role in preventing lymph node metastasis, which is crucial for patient outcomes.
Three genes related to stromal integrity were significantly downregulated in lymph node metastases compared to primary tumors.
Single-cell RNA-seq revealed differential gene expression specific to fibroblast populations in primary tumors and metastases.
The depletion of protective fibroblasts correlates with increased tumor progression and poorer patient survival outcomes.

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Multi-omics analysis identifies fibroblast roles in lymph node metastasis, suggesting novel therapeutic targets.

Rastad et al. (2025) studied this question.

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