August 22, 2025PLoS ONEOpen Access

Ischemic duration determines extent of cardiac remodeling, and both early and delayed reperfusion prevent fatal cardiac rupture: Model comparison

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Cardiac rupture incidence was significantly lower with early reperfusion compared to myocardial infarction (MI) models, highlighting its importance.
Infarct size and myocyte apoptosis increased with prolonged ischemia, with inflammatory responses correlating to cardiac damage.
Assessment involved male C57 mice subjected to ischemia/reperfusion and permanent occlusion injuries, comparing outcomes post-injury.
Early reperfusion improves recovery and healing of the myocardium, indicating potential therapeutic avenues for cardiac injuries.

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Research demonstrates how ischemia duration impacts cardiac remodeling in C57 mice, suggesting early reperfusion effectively reduces rupture risk.

Zhao et al. (2025) studied this question.

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Research demonstrates how ischemia duration impacts cardiac remodeling in C57 mice, suggesting early reperfusion effectively reduces rupture risk.