Secondary analysis associates maternal characteristics with polygenic risk scores for gestational diabetes in participants, suggesting genetic influences on outcomes.
Key Points
Higher polygenic risk scores for diabetes are linked to increased rates of gestational diabetes, pointing to genetic factors influencing maternal health.
Participants with the highest PRS had a family history of diabetes at 61.9%, significantly higher than those in lower quartiles (p = 0.03).
Observational cohort analysis involving 411 pregnant individuals assessed DNA to determine ancestry-adjusted PRS results.
These findings may assist healthcare providers in better predicting GDM risk based on genetic and clinical characteristics.