August 22, 2025Open Access

DNA-binding-independent mechanisms of metabolic regulation by the Drosophila FOXO transcription factor

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Genomic engineering shows distinct transcriptional roles of FOXO in metabolism and stress responses in Drosophila, suggesting novel pathways.

DNA-binding deficiency in dFOXO affects lipid mobilisation during starvation, indicating its role in metabolic regulation.
Key findings show that dFOXO influences female fecundity and lifespan, highlighting its multifaceted roles in Drosophila.
Genomic engineering of dFOXO enables analysis of canonical and non-canonical functions in vivo, revealing novel mechanisms.
Identifying transcriptional changes under starvation showcases how dFOXO regulates metabolic pathways beyond DNA interactions.

Bustos et al. (2025) studied this question.

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Genomic engineering shows distinct transcriptional roles of FOXO in metabolism and stress responses in Drosophila, suggesting novel pathways.