Review highlights progress in small-molecule inhibitors of glycolysis, glutamine metabolism, and fatty acid synthesis, indicating new therapeutic options.
Key Points
Targeting metabolism in cancer therapy shows promise by utilizing small molecules for effective treatment.
Recent developments include inhibitors of glycolysis, glutamine metabolism, and fatty acid synthesis to combat cancer.
Analysis of mechanisms reveals specific enzyme targets like LDH, HK2, PKM2, GLS, and FASN in cancer cells.
Strategies focused on metabolism could lead to next-generation anticancer agents with higher efficacy and less toxicity.