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August 22, 2025Journal of Medical SciencesOpen Access

Effect of Hyperventilation Prior to CO2 Insufflation in Laparoscopic Cholecystectomy: A Randomized Controlled Trial

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Authors

SNShuchi NigamUSUsha ShuklaRGRahul Gupta

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Overview

Randomized controlled trial showed improved hemodynamics in patients with adjusted end-tidal CO2 during laparoscopic cholecystectomy, suggesting hyperventilation may enhance safety.

Key Points

  • Hyperventilation before CO2 insufflation improved mean arterial pressure significantly, indicating better hemodynamic stability after 5 and 10 minutes.
  • Group 2 patients showed a higher mean arterial pressure of 94.80 compared to 87.07 in group 1, with significant differences noted at both time points.
  • A randomized controlled trial involved 30 patients undergoing laparoscopic cholecystectomy with controlled tidal volume and end-tidal CO2 adjustments.
  • These findings suggest hyperventilation could be a simple solution in restricted-resource settings for enhancing surgical safety.

Cite This Study

Nigam et al. (2025) studied this question.

synapsesocial.com/papers/68af706e7567bf4f94febf02https://doi.org/10.4103/jmedsci.jmedsci_60_25
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