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August 21, 2025World Journal of Cardiology

Efficacy and safety of incretin co-agonists: Transformative advances in cardiometabolic healthcare

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Authors

SBSowrabha BhatCFCornelius James FernandezVLVijaya M. Lakshmi

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Overview

Evidence review demonstrates beneficial effects of GLP-1 co-agonists on weight loss in cardiometabolic health, indicating improved patient outcomes.

Key Points

  • Incretin co-agonists significantly improve cardiometabolic health outcomes by reducing weight and glycated hemoglobin levels, enhancing metabolic profiles.
  • Dual GIP/GLP-1 receptor agonist tirzepatide shows lower gastrointestinal side effects while promoting weight loss and metabolic health benefits.
  • Many incretin co-agonists are designed for once-weekly administration, providing a more convenient therapeutic option for patients.
  • Promising pipeline agents, including novel dual and triple agonists, highlight potential for superior weight loss and cardiovascular outcomes in treatments.

Cite This Study

Bhat et al. (2025) studied this question.

synapsesocial.com/papers/68af70627567bf4f94feb901https://doi.org/10.4330/wjc.v17.i8.107991
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