Mechanisms and Therapeutic Advances of PXR in Metabolic Diseases and Cancer

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Review reveals PXR's impact on metabolic diseases and cancer, suggesting new therapeutic strategies.

PXR regulation affects glucose metabolism and insulin sensitivity in type 2 diabetes mellitus, impacting disease progression.
Mechanisms include modulating drug-metabolizing enzymes, lipid metabolism, and inflammatory pathways, highlighting the receptor's central role.
PXR shows protective effects in atherosclerosis through cholesterol metabolism and anti-inflammatory actions.
Therapeutic strategies targeting PXR demonstrate promise in combating metabolic diseases and various cancers.

Bi et al. (2025) studied this question.

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