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August 21, 2025PeerJOpen Access

The effects of exercise on oxidative stress MDA and SOD in patients with type 2 diabetes: a systematic review and meta-analysis

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Authors

CQChen QiuSLShufan LiSJShuqi JiaShanghai University of Sport

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Implication

Systematic review shows exercise reduces oxidative stress indicators MDA and SOD in type 2 diabetes patients, suggesting effective intervention strategies.

Key Points

  • Exercise significantly improves malondialdehyde (MDA) and superoxide dismutase (SOD) in type 2 diabetes patients, indicating positive effects on oxidative stress.
  • The meta-analysis included 11 articles and a total of 1,111 patients, finding a notable reduction in MDA with SMD = −1.29 and improvement in SOD with SMD = 0.59.
  • Subgroup analysis reveals that aerobic and combined exercises lasting more than 12 weeks significantly enhance oxidative stress indicators.
  • Good quality literature was assessed, showing moderate evidence for MDA and high-quality evidence for SOD in improving oxidative stress in type 2 diabetes.

Cite This Study

Qiu et al. (2025) studied this question.

synapsesocial.com/papers/68af70627567bf4f94feb629https://doi.org/10.7717/peerj.19814
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Also Consider

Synapse has enriched one closely related paper. Consider it for comparative context:

  1. 1Clinical Review of Antidiabetic Drugs: Implications for Type 2 Diabetes Mellitus Management2017 · 1,526 citations