August 21, 2025Open Access

Ancestry Specific Polygenic Risk Score, Dietary Patterns, Physical Activity and Incident Type 2 Diabetes

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Authors

DHDale S. Hardy JGJane T. Garvin TLTennille Leak-Johnson

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Implication

Longitudinal analysis reveals dietary patterns and physical activity influence type 2 diabetes risk in diverse ancestries, suggesting targeted interventions.

Key Points

Higher incident type 2 diabetes risk is found in African Americans with high-risk polygenic risk scores, showing an odds ratio of 1.61.
Protective effects against type 2 diabetes were observed with the DASH and Mediterranean diets, particularly in high-risk individuals.
Longitudinal study utilized data from over 9,000 individuals across two ancestries to assess diet and lifestyle interactions.
Implementing DASH and Mediterranean diets with increased physical activity may reverse harmful molecular pathways linked to type 2 diabetes.

Cite This Study

Hardy et al. (2025) studied this question.

synapsesocial.com/papers/68af6d907567bf4f94feb10a https://doi.org/10.21203/rs.3.rs-7105280/v1

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Implication

Longitudinal analysis reveals dietary patterns and physical activity influence type 2 diabetes risk in diverse ancestries, suggesting targeted interventions.

Ancestry Specific Polygenic Risk Score, Dietary Patterns, Physical Activity and Incident Type 2 Diabetes

Discussion

Member takes

Implication

Key Points

Cite This Study

Ancestry Specific Polygenic Risk Score, Dietary Patterns, Physical Activity and Incident Type 2 Diabetes

Discussion

Member takes

Implication

Key Points

Cite This Study

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Also Consider