Cohort study finds that PCR-based testing improves treatment effectiveness for Helicobacter pylori infection, suggesting better outcomes with guided therapy.
Key Points
PCR-based diagnosis achieved a sensitivity of 99.7%, significantly higher than histology and culture results.
Among patients treated, 84.9% received susceptibility-guided triple therapy, showing eradication rates of 98.1%.
Clarithromycin resistance was found in 22.6% and levofloxacin resistance in 18.6% of tested cases, highlighting antibiotic susceptibility concerns.
The PCR-based strategy was more cost-effective than traditional methods, making it easier for routine clinical implementation.