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August 20, 2025Journal of Evidence-Based MedicineOpen Access

The Efficacy of Zinc Supplementation Alone or in Combination for Improving Pregnancy and Infant Outcomes: A Systematic Review and Meta‐Analysis

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Authors

SDSha DiaoFYFeng YuanXPXue Peng

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Overview

Systematic review finds zinc supplementation improves pregnancy outcomes in healthy women and high-risk groups, suggesting potential benefits yet limited by bias risks.

Key Points

  • Zinc supplementation alone results in improved serum zinc levels during the second and third trimesters, and benefits such as larger neonatal birth size.
  • Analysis includes 77 randomized controlled trials assessing various characteristics and participant subgroups, highlighting significant findings.
  • Qualitative synthesis indicates potential advantages for high-risk groups, although combination therapies showed no added benefits against standard treatments.
  • Highlights the necessity for further research to solidify the implications of zinc's role in prenatal care and infant health.

Cite This Study

Diao et al. (2025) studied this question.

synapsesocial.com/papers/68af6d847567bf4f94fea754https://doi.org/10.1111/jebm.70061
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