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August 15, 2025Frontiers in PharmacologyOpen Access

Identification of biomarkers based on ubiquitin-correlated genes for predicting immune profile and drug sensitivity in lung adenocarcinoma

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Authors

YLYue LiWTWei TianCCChen Chen

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Overview

Integration of ubiquitin-associated gene modules predicts immune profile and drug sensitivity in lung adenocarcinoma, suggesting new diagnostic options.

Key Points

  • Low-risk lung adenocarcinoma patients exhibit significantly better overall survival than high-risk counterparts, highlighting the importance of prognostic markers.
  • A total of 197 ubiquitin-related genes were identified through WGCNA analysis, which demonstrated a link with immune cell infiltration.
  • Cox regression analysis was used to develop a risk model for lung adenocarcinoma prognosis based on gene expression profiles.
  • Findings indicate that the expression of model genes correlates negatively with immune cell infiltration, and certain drugs showed potential sensitivity profiles.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68af6c107567bf4f94fea312https://doi.org/10.3389/fphar.2025.1646396
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