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August 15, 2025Frontiers in MedicineOpen Access

Case Report: Pituitary hyperplasia secondary to long-neglected severe primary hypothyroidism: a case of misdiagnosis and lessons learned

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Authors

SDSi-na DuJSJiawei SunCWC.H. Wang

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Overview

Case report reveals pituitary hyperplasia linked to primary hypothyroidism, suggesting surgical mismanagement implications.

Key Points

  • Pituitary hyperplasia was identified due to long-neglected primary hypothyroidism, and careful evaluation is critical.
  • Initial bromocriptine treatment was ineffective, which highlighted the misdiagnosis and led to further surgical intervention.
  • MRI revealed significant pituitary enlargement, contributing to symptoms such as menstrual irregularities and hyperprolactinemia.
  • Postoperative thyroid hormone therapy restored normal thyroid function, underscoring the need for accurate diagnosis of hypothyroidism.

Cite This Study

Du et al. (2025) studied this question.

synapsesocial.com/papers/68af6c0b7567bf4f94fe9f93https://doi.org/10.3389/fmed.2025.1601190
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