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August 15, 2025ACS OmegaOpen Access

Tamarind-Derived Trypsin Inhibitor as a Potential Therapeutic Agent for Obesity: Evidence from In Vitro and Zebrafish Models

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Authors

ASAndré Gustavo Pires de SousaRSRaphael Paschoal SerquizALAna Carolina Luchiari

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Overview

In vitro and zebrafish models demonstrate TTI's potential to reduce body weight in obesity, indicating a novel therapeutic approach.

Key Points

  • TTI significantly reduced body weight in obese zebrafish compared to controls, providing evidence for its therapeutic value.
  • The study found TTI inhibition of lipase activity to be 83% in vitro, with a measured IC50 of 1.59 × 10–9 mol L–1.
  • Assessment used diet-induced obesity models in zebrafish to evaluate TTI's effects on body weight and lipid profiles.
  • TTI shows promise as a treatment for obesity and dyslipidemia, highlighting its potential benefits against related health issues.

Cite This Study

Sousa et al. (2025) studied this question.

synapsesocial.com/papers/68af6bff7567bf4f94fe9adbhttps://doi.org/10.1021/acsomega.5c05693
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