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August 21, 2025Angewandte Chemie

HerTACs Enable Tumor‐Selective Lysosomal Degradation of Membrane and Extracellular Proteins via HER2 Trafficking

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Authors

SHShipeng HeWHWenjing HuangYZYaojin Zhu

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Overview

Novel HerTACs enable targeted degradation of membrane proteins in HER2-positive tumors, suggesting new avenues for precision oncology.

Key Points

  • HerTACs achieved effective degradation of extracellular proteins, enhancing treatment options for breast cancer.
  • The first-generation HerTAC demonstrated significant activity, with a degradative concentration of 156 nM against PD-L1.
  • This approach incorporates lysosome-targeting techniques, revolutionizing how tumor-selective degradation is achieved.
  • It highlights the potential for expanding treatment options in cancer through targeted protein degradation strategies.

Cite This Study

He et al. (2025) studied this question.

synapsesocial.com/papers/68af6bf77567bf4f94fe9777https://doi.org/10.1002/ange.202511467
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