This analysis compares saliva, subgingival plaque, and gingival crevicular fluid in periodontitis, revealing key insights into microbial and host profiles.
Key Points
Saliva effectively screens for microbiome and proteome but may miss specific periodontal pathogens.
A total of 277 microbial taxa were identified in saliva and plaque, with 93 showing significant differences.
Shotgun sequencing and mass spectrometry proteomics were employed for comprehensive microbial and protein analysis.
Saliva shares numerous immune pathways with GCF, highlighting its value in broader diagnostic contexts.