Multitargeted Regulation of Rheumatoid Arthritis by Gut Microbiota

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Novel insights reveal that gut microbiota dysbiosis significantly contributes to rheumatoid arthritis pathology, and targeting it provides new therapeutic avenues.
Key metabolites like short-chain fatty acids have vital roles in maintaining immune homeostasis and modulating disease mechanisms in rheumatoid arthritis.
Various microbiota-targeting strategies including precision diets and fecal microbiota transplantation are explored for efficacy in rheumatoid arthritis treatment.
Developing predictive models for microbiota, metabolites, and immune phenotypes is essential for advancing personalized interventions in rheumatoid arthritis.

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Review uncovers gut microbiota's impact on immune mechanisms in rheumatoid arthritis, suggesting new intervention strategies.

Zhiqian Tong (2025) studied this question.

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