Established and Emerging Roles of Epigenetic Regulation in Diabetic Cardiomyopathy

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Review highlights the role of epigenetic regulation on diabetic cardiomyopathy progression and related cardiovascular complications.

Epigenetic alterations play a crucial role in the development of diabetic cardiomyopathy, influencing its progression and severity.
Significant epigenetic changes, including DNA methylation and histone modifications, are observed in patients with type 2 diabetes.
Analysis reveals a lack of effective treatments for diabetic cardiomyopathy due to its complex nature and unclear mechanisms.
Understanding the unique epigenetic alterations in diabetic hearts could lead to new treatment targets and better management options.

Russell‐Hallinan et al. (2025) studied this question.

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