August 19, 2025Open Access

Efficacy and Outcomes of Pharmacological Treatments for Headaches after Traumatic Brain Injury: A Systematic Review

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Most studies noted improvements in headache frequency and intensity, indicating potential benefits from treatment options.
Sixteen studies were included, revealing that some treatments improved both headache burden and quality of life for patients.
Randomized controlled trials showed that Erenumab may help persistent headaches, especially in civilian populations, improving their overall quality of life.
Due to limited high-quality evidence, caution is advised in using pharmacological treatments for post-traumatic headaches; further research is necessary.

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Implication

Systematic review reveals mixed efficacy of pharmacological treatments for headaches post-traumatic brain injury, suggesting future research on personalized approaches.

Cite This Study

Saleh et al. (2025) studied this question.

synapsesocial.com/papers/68af4093cf1dd9ea359ec4b4 https://doi.org/10.1101/2025.08.11.25332976

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Implication

Systematic review reveals mixed efficacy of pharmacological treatments for headaches post-traumatic brain injury, suggesting future research on personalized approaches.

Efficacy and Outcomes of Pharmacological Treatments for Headaches after Traumatic Brain Injury: A Systematic Review

Key Points

Discussion

Implication

Cite This Study

Efficacy and Outcomes of Pharmacological Treatments for Headaches after Traumatic Brain Injury: A Systematic Review

Key Points

Discussion

Implication

Cite This Study