August 20, 2025Frontiers in ImmunologyOpen Access

Assessing the impact of TET2 and TET3 deletion in TCRalpha and TCRbeta repertoire in murine CD4 T cells in physiological and pathophysiological conditions

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Analysis shows diminished diversity in TCR repertoire of CD4 T cells lacking TET2 and TET3, suggesting implications for immune responses.

Expanded Tet2/3 DKO CD4 cells exhibit reduced diversity and an oligoclonal TCR repertoire in the periphery, impacting immune functionality.
TCR sequencing demonstrates that both wild type and Tet2/3 DKO CD4 cells are polyclonal, revealing variability in T cell populations.
Investigative focus on Tet2/3 DKO CD4 cells highlights the importance of TET proteins in shaping TCRα and TCRβ repertoires during development.
These findings may inform future studies regarding TET proteins and their roles in T cell development and immune response.

Äijö et al. (2025) studied this question.

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August 20, 2025Frontiers in ImmunologyOpen Access

View Full Paper

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Authors

Analysis shows diminished diversity in TCR repertoire of CD4 T cells lacking TET2 and TET3, suggesting implications for immune responses.

Expanded Tet2/3 DKO CD4 cells exhibit reduced diversity and an oligoclonal TCR repertoire in the periphery, impacting immune functionality.
TCR sequencing demonstrates that both wild type and Tet2/3 DKO CD4 cells are polyclonal, revealing variability in T cell populations.
Investigative focus on Tet2/3 DKO CD4 cells highlights the importance of TET proteins in shaping TCRα and TCRβ repertoires during development.
These findings may inform future studies regarding TET proteins and their roles in T cell development and immune response.

Äijö et al. (2025) studied this question.

View Full Paper

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