In vitro assessment of α-glucosidase inhibitory activity and compound prediction in Phyllanthus niruri from West Java Indonesia

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The study found α-glucosidase inhibitory activity with an IC50 of 1.48 μg/ml from Phyllanthus niruri.
UPLC-QTOF/MS identified key compounds like corilagin and gallic acid dimethyl ester in the extract.
Molecular docking simulations indicated favorable interactions of these compounds with α-glucosidase.
These findings highlight Phyllanthus niruri as a promising natural product for diabetes management.

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Assessment demonstrates strong α-glucosidase inhibitory activity in Phyllanthus niruri extracts, suggesting potential for diabetes treatment.

Rosidah et al. (2025) studied this question.

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Assessment demonstrates strong α-glucosidase inhibitory activity in Phyllanthus niruri extracts, suggesting potential for diabetes treatment.