Cross-sectional study shows serum IL-18 levels predict acute kidney injury in sepsis, indicating potential for early diagnosis.
Key Points
Serum IL-18 levels significantly higher in patients with acute kidney injury compared to non-AKI patients, showing its potential as a predictive biomarker.
The study analyzed 68 sepsis patients using the ELISA method for serum IL-18 and applied KDIGO criteria for AKI diagnosis.
Receiver operating characteristic analysis indicated a good diagnostic accuracy with an area under the curve of 0.792 and 82.4% sensitivity.
Serum IL-18 increases the risk of developing acute kidney injury by 7.3% for each 1-unit increase in its level.