August 20, 2025PharmaceuticalsOpen Access

Novel Indole-Based Sulfonylhydrazones as Potential Anti-Breast Cancer Agents: Synthesis, In Vitro Evaluation, ADME, and QSAR Studies

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Synthesis and evaluation reveal selective cytotoxicity in breast cancer cell lines, suggesting a promising therapeutic avenue.

Compound 3b achieved significant cytotoxicity against MCF-7 cells with an IC50 of 4.0 μM, indicating potent effects specifically in that cell line.
The novel indole-based sulfonylhydrazones were evaluated for cytotoxicity using the MTT assay against MCF-7 and MDA-MB-231 breast cancer cell lines.
Initial drug likeness and ADME properties were assessed through in silico screenings prior to experimental synthesis.
QSAR analysis identified key structural features that enhance cytotoxic activity, laying groundwork for future drug development.

Angelova et al. (2025) studied this question.

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August 20, 2025PharmaceuticalsOpen Access

View Full Paper

Ask AI

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Authors

Synthesis and evaluation reveal selective cytotoxicity in breast cancer cell lines, suggesting a promising therapeutic avenue.

Compound 3b achieved significant cytotoxicity against MCF-7 cells with an IC50 of 4.0 μM, indicating potent effects specifically in that cell line.
The novel indole-based sulfonylhydrazones were evaluated for cytotoxicity using the MTT assay against MCF-7 and MDA-MB-231 breast cancer cell lines.
Initial drug likeness and ADME properties were assessed through in silico screenings prior to experimental synthesis.
QSAR analysis identified key structural features that enhance cytotoxic activity, laying groundwork for future drug development.

Angelova et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark