Validation of Biomarkers Z‐AAT Polymers and Fibrinopeptide Aα‐Val⁵⁴¹ in Peripheral Blood of Patients With pi*ZZ Alpha‐1 Antitrypsin Deficiency

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Polymers of Z-AAT and Aα-Val 541 levels significantly decrease after liver transplantation.
Before transplantation, elevated Z-AAT polymers were detected in patients, but these were nearly absent post-surgery.
Assessment with a monoclonal antibody confirmed polymer presence; a Europium-based immunoassay measured fibrinopeptide levels.
Results highlight the potential benefits of liver transplantation in managing alpha-1 antitrypsin deficiency.

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Observational analysis reveals reduced Z-AAT polymers and Aα-Val 541 in Pi*ZZ patients post-liver transplantation, suggesting improved outcomes.

Kappe et al. (2025) studied this question.

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Observational analysis reveals reduced Z-AAT polymers and Aα-Val 541 in Pi*ZZ patients post-liver transplantation, suggesting improved outcomes.