A Systematic Review of Diagnostic Approaches for Pediatric Epilepsy: An Evidence-Based Framework from Clinical Assessment to Precision Medicine

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Systematic review identifies key diagnostic modalities, highlighting precision medicine's role in pediatric epilepsy management.

The diagnostic process utilizes clinical history and neurological examination to differentiate seizures effectively, and is crucial for accurate diagnosis.
Electroencephalography achieves an initial diagnostic yield of about 52%, with long-term monitoring resolving 75% of complex cases.
Advanced techniques in neuroimaging significantly enhance diagnostic accuracy, identifying lesions in 33-44% of children with epilepsy.
Genetic testing shows a yield of 25-48% for early-onset and severe cases, impacting clinical management in 85% of diagnosed children.

Windaswara et al. (2025) studied this question.

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